Yes, but you work with College Board's SSD office directly rather than through a school coordinator, which adds time. Allow for that on top of College Board's approval time of up to seven weeks, and expect to supply the documentation yourself.
The absence of a school coordinator is the real cost, because that role normally chases paperwork and follows up on requests. Homeschooling families should assume they are the coordinator and build in extra weeks for the back-and-forth that a school would otherwise absorb.
The full picture, with the surrounding detail, is in SAT Accommodations Deadlines 2026-27: Every Test Date.